Serotyping Pneumococcal Meningitis Cases in the African Meningitis Belt by Use of Multiplex PCR with Cerebrospinal Fluid
- 1 February 2010
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 48 (2) , 612-614
- https://doi.org/10.1128/jcm.01402-09
Abstract
We reformulated a multiplex PCR algorithm for serotyping of pneumococcal meningitis directly on cerebrospinal fluid (CSF). Compared to established methods on isolates, CSF-based PCR had at least 80% sensitivity and 100% specificity. In regional meningitis surveillance, CSF-based PCR increased the serotype information yield from 40% of cases (isolate testing) to 90%.Keywords
This publication has 10 references indexed in Scilit:
- Laboratory Diagnosis of Invasive Pneumococcal DiseaseClinical Infectious Diseases, 2008
- The epidemiology of Neisseria meningitidis meningitis in Togo during 2003–2005Vaccine, 2007
- Sequential multiplex PCR for determining capsular serotypes of pneumococci recovered from Brazilian childrenJournal of Medical Microbiology, 2007
- Sequential multiplex PCR for identifying pneumococcal capsular serotypes from south-Saharan African clinical isolatesJournal of Medical Microbiology, 2007
- The preventable burden of pneumococcal disease in the developing worldVaccine, 2007
- Epidemiological and Molecular Characteristics of a Highly Lethal Pneumococcal Meningitis Epidemic in Burkina FasoClinical Infectious Diseases, 2006
- Sequential Multiplex PCR Approach for Determining Capsular Serotypes of Streptococcus pneumoniae IsolatesJournal of Clinical Microbiology, 2006
- The establishment of Neisseria meningitidis serogroup W135 of the clonal complex ET-37/ST-11 as an epidemic clone and the persistence of serogroup A isolates in Burkina FasoMicrobes and Infection, 2005
- Bacterial Meningitis in Burkina Faso: Surveillance Using Field-Based Polymerase Chain Reaction TestingClinical Infectious Diseases, 2005
- Serotyping Streptococcus pneumoniae by Multiplex PCRJournal of Clinical Microbiology, 2003