Metabolism of budralazine, a new antihypertensive agent. II. Metabolic pathways of budralazine in rats.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (4) , 830-835
- https://doi.org/10.1248/cpb.25.830
Abstract
Metabolic pathways of budralazine were studied in vivo and in vitro. 3-Methyl-s-triazolo[3,4-a]phthalazine, 1 of the major metabolites of budralazine, was mainly biotransformed via 1-hydrazinophthalazine. s-Triazolo[3,4-a]phthalazine was biotransformed via 1-hydrazinophthalazine. Experiments using liver preparations of rat were discussed briefly.This publication has 2 references indexed in Scilit:
- Metabolism of Budralazine, a New Antihypertensive Agent. I. Identification of the Metabolites of Budralazine in RatsCHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- A Metabolite of 1-Hydrazinophthalazine (Hydralazine).Experimental Biology and Medicine, 1959