Role of the Adrenals in Stress Induced Resistance to Anaphylactic Shock

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Abstract
Summary: An increase in resistance to passive anaphylaxis in mice regularly follows acute, 6 hr, or chronic, 6 hr per day for 4 weeks, shuttle box stress. This increase in resistance did not develop in stressed, adrenalectomized mice. Treatment of adrenalectomized mice with hydrocortisone acetate resulted in an increase in resistance to anaphylaxis. Acute stress exerted an additive protective effect to that of hydrocortisone in intact but not in adrenalectomized animals. The incidental stress of isolation resulted in a slight but definite increase in resistance to anaphylaxis.