Biochemical Significance of Serum Glycoproteins. I. Changes in Rat Serum Following Injury

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Abstract
Changes produced in distribution of serum protein of rats injured by removal of 2.5 cm circle of skin just caudal to the scapulae or by implanting subcutaneously a 200 mg piece of Ivalon sponge were studied using paper electrophoresis. The electrophoretic distribution of glycoproteins was determined by measuring the concentration of hexosamine in 4 zones, albumin plus [alpha]1, [alpha]2, [beta] and gamma-globulins. Parallel elevations of serum hexosamines on proteins which are classified as [alpha]2 and [beta]-globulins were observed in response to 2 kinds of experimental injury. These increases reached maximum proportions 2 to 4 days after injury.