Diagnostic Ultrasound: Effects on the DNA and Growth Patterns of Animal Cells

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Abstract
The effects of diagnostic levels of ultrasound on DNA of HeLa [human cervical carcinoma] cells included increased immunoreactivity to antinucleoside antibodies in G1 cell (strongly suggestive of unwinding of the helix or single-strand break induction) and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl [clone]8, loss of contact inhibition with a criss-crossed growth pattern was seen. In 1 experiment, tumors developed in synegeneic mice at the site of injection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects of DNA and growth patterns of animal cells.