The metabolism of sulphonamides
- 1 January 1947
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 41 (2) , 206-212
- https://doi.org/10.1042/bj0410206
Abstract
In the rabbit p-aminomethyl-benzenesulphonamide HCL (ambamide) is rapidly oxidized and excreted in the urine as p-carboxybenzenesulphonamide (I); up to 84% of the ambamide was so recovered. I and its 3-hydroxyderivative, also p-acetylamidomethylbenzene-sulphonamide, are excreted unchanged. p-Methylsulphonyl-benzylamine HC1 (V 335) is excreted as the benzoic acid deriv. (II). Neither I nor II has any antibacterial activity. Ambamide and V 335 may be inactivated by amine oxidase and these drugs may act by interfering with the utilization by bacteria of subtances containing aliphatic primary amino groups.This publication has 12 references indexed in Scilit:
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