THE EFFECT OF PITUITARY ADRENOTROPHIC HORMONE ON THE CHOLESTEROL AND ASCORBIC ACID CONTENT OF THE ADRENAL OF THE RAT AND THE GUINEA PIG1

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Abstract
The injn. of highly purified adrenotrophic hormone (A.C.T.) into rats and guinea pigs is followed by a prompt fall in adrenal ascorbic acid and a slower fall in adrenal cholesterol. The levels of these substances in other tissues are not affected. Following such injns., the adrenal cholesterol slowly returns to the initial levels in 24 hrs. in both spp. The rate of return of adrenal ascorbic acid is quite rapid in the rat, whereas in the guinea pig the level remains depressed for some hrs. and then slowly rises, although 24 hrs. after the injn. the level is still subnormal. Coincident with the fall in adrenal ascorbic acid and cholesterol there is an increased deposition of liver glycogen in both the rat and guinea pig. It is suggested that these changes in adrenal ascorbic acid and cholesterol under the influence of A.C.T. are associated with the formation and release of the adrenal cortical hormones.