Surgical Adhesives in Ophthalmology

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Abstract
Cyanoacrylate adhesives were tested for tissue tolerance in rabbit eyes. The monomers were applied on deepithelialized corneas, and the polymers were implanted intracorneally and in the anterior chamber. The following classification is made based on clinical and histological observations. Best tolerated: n-decyl, n-octyl, n-heptyl, n-hexyl, n-butyl, and isobutyl 2-cyanoacrylate; less well tolerated: β,β,β-trifluoroisopropyl 2-cyanoacrylate; and least tolerated: methyl 2-cyanoacrylate. The clinical applications of cyanoacrylate adhesives in corneal and retinal surgery are reviewed, including, 1) sealing of traumatic perforations and ulcers in the cornea, 2) attaching artificial membranes to the anterior surface of the cornea (artificial epithelium) and to the posterior surface (artificial endothelium), 3) adhesives with penetrating corneal prostheses, 4) sealing choroidal perforations, and 5) sutureless scleral buckles.

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