Isolation and properties of a 7 S rat immunoglobulin different from IgG

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Abstract
A 7 S rat immunoglobulin, of rapid electrophoretic mobility, was characterized and isolated from normal or hyperimmune rat serum and was designated “IgR”. This immunoglobulin belongs to a class different from IgG and was originally described as IgA. IgR has a molecular weight of 160 000, is present in the serum and milk as a monomer and is readily absorbed by the intestine of suckling rats. In hyperimmunized animals, about 20 % of the antibodies were of the IgR class. IgR is devoid of anaphylactic capacity and no homologies could be established between it and immunoglobulins of other animal species.

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