Burst Discharge in Mammalian Neuroendocrine Cells Involves an Intrinsic Regenerative Mechanism
- 9 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4615) , 1050-1052
- https://doi.org/10.1126/science.6879204
Abstract
Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.This publication has 26 references indexed in Scilit:
- Dye Transfer Through Gap Junctions Between Neuroendocrine Cells of Rat HypothalamusScience, 1981
- Relative Efficiency of Neural Firing Patterns for Vasopressin Release in vitroNeuroendocrinology, 1981
- Synthesis, Transport, and Release of Posterior Pituitary HormonesScience, 1980
- Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic MechanismsNeuroendocrinology, 1980
- Phasically firing neurons in long-term cultures of the rat hypothalamic supraoptic area: Pacemaker and follower cellsBrain Research, 1979
- Peptides in the Brain: The New Endocrinology of the NeuronScience, 1978
- Aspects of Hypothalamic Regulation of the Pituitary GlandScience, 1978
- Bursting Neural Networks: A ReexaminationScience, 1978
- The existence of facilitatory axon collaterals in neurosecretory cells of the hypothalamusBrain Research, 1973
- THE MILK-EJECTION REFLEX OF THE RAT: A 20- TO 40-FOLD ACCELERATION IN THE FIRING OF PARAVENTRICULAR NEURONES DURING OXYTOCIN RELEASEJournal of Endocrinology, 1973