Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase fromCryptococcus neoformans
Open Access
- 1 September 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (9) , 5412-5417
- https://doi.org/10.1128/iai.71.9.5412-5417.2003
Abstract
A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized orCryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.Keywords
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