Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol‐10 and polyunsaturated fatty acid content

Abstract
At an early stage of oxidation induced by Cu2+, the rate of oxidative modification of human low density lipoprotein (LDL) from healthy donors correlated negatively to its ubiquinol‐10 (r = −0.58, P < 0.01) and positively to its polyunsaturated fatty acid (PUFA) (r = 0.53, P < 0.05) content. The PUFA/ubiquinol‐10 ratio was the best predictor of LDL susceptibility to oxidation (r = 0.68, P < 0.01). No significant correlation between LDL oxidizability and its α‐tocopherol content was found at any oxidation stage. It is suggested that ubiquinol‐10 plays a central role in the early protection of LDL PUFAs against Cu2+‐induced oxidation whereas α‐tocopherol posesses both pro‐ and antioxidant activity.

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