Experimental Chemotherapy of Burns and Shock. VIII. I. Effects of Potassium Administration, of Sodium Loss, and Fluid Loss in Tourniquet Shock

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Abstract
A previously described method of producing standardized traumatic shock in mice was employed. A comparison of the toxicity of K for normal and shocked mice revealed that the toxicity in shock increased 800% by the intraven. route and 560% by the intraperit. route. The toxicities of quinidine and MgSO4 were detd. under similar conditions (as drug controls, to evaluate any general increase in susceptibility due to the condition of the animals). The increased toxicity of quinidine in shock amounted to only 75% above normal, and Mg only 51%. Fluid and Na loss were produced by the intraperit. injns. of glucose solns. Employing the same techniques it was demonstrated that a large increase in susceptibility to Na and fluid loss exists in shock.