Urinary cyclic adenosine monophosphate in young adults and elderly subjects.
- 1 January 1976
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 29 (1) , 69-72
- https://doi.org/10.1136/jcp.29.1.69
Abstract
The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between cAMP excretion and age demonstrated a progressive decrease from the age of 70 to the tenth decade. Many different factors could account for the reduced urinary cAMP excretion in elderly subjects: a decline in the reactivity of the adenyl cyclase-cAMP system related to physiological ageing; reduced physical activity; a reduction in the glomerular filtration rate or decreased production of cAMP by tubular cells in the senile kidney.Keywords
This publication has 20 references indexed in Scilit:
- PRIMARY HYPERPARATHYROIDISMMedicine, 1974
- Sources of Cyclic Nucleotides in PlasmaJournal of Clinical Investigation, 1974
- URINARY CYCLIC ADENOSINE MONOPHOSPHATE AS AN AID IN THE DIAGNOSIS OF HYPERPARATHYROIDISMThe Lancet, 1973
- Effects of parathyroid hormone on plasma and urinary adenosine 3′,5′-monophosphate in manJournal of Clinical Investigation, 1970
- Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urineJournal of Clinical Investigation, 1970
- Kinetic parameters and renal clearances of plasma adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in manJournal of Clinical Investigation, 1970
- EXERCISE AND URINARY EXCRETION OF CYCLIC A.M.P.The Lancet, 1970
- Renal Adenyl Cyclase: Anatomically Separate Sites for Parathyroid Hormone and VasopressinScience, 1968
- EFFECTS OF VASOPRESSIN AND WATER-LOAD ON URINARY ADENOSINE-3',5'-CYCLIC MONOPHOSPHATEThe Lancet, 1966
- AGE CHANGES IN GLOMERULAR FILTRATION RATE, EFFECTIVE RENAL PLASMA FLOW, AND TUBULAR EXCRETORY CAPACITY IN ADULT MALESJournal of Clinical Investigation, 1950