Peptide synthesis. Part 7. Solid-phase synthesis of conotoxin G1
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2065-2073
- https://doi.org/10.1039/p19850002065
Abstract
The neurotoxin conotoxin G1 from Conus geographus has been synthesised by a solid-phase method using fluorenylmethoxycarbonylamino acids and a polar, poly(dimethylacrylamide)-based support. The two disulphide bridges were formed selectively by differential protection of cysteine residues using S-acetamidomethyl and S-t-butylsulphenyl groups.This publication has 7 references indexed in Scilit:
- Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivativesBiochemistry, 1984
- Peptide synthesis. Part 3. Comparative solid-phase syntheses of human β-endorphin on polyamide supports using t-butoxycarbonyl and fluorenylmethoxycarbonyl protecting groupsJournal of the Chemical Society, Perkin Transactions 1, 1983
- Peptide synthesis. Part 4. Solid-phase syntheses of peptides related to gastrinJournal of the Chemical Society, Perkin Transactions 1, 1983
- Acid‐labile resin linkage agents for use in solid phase peptide synthesisInternational Journal of Peptide and Protein Research, 1982
- Peptide synthesis. Part 2. Procedures for solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptideJournal of the Chemical Society, Perkin Transactions 1, 1981
- Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide)Journal of the Chemical Society, Perkin Transactions 1, 1981
- The Synthesis of Cystine Peptides by Iodine Oxidation of S‐Trityl‐cysteine and S‐Acetamidomethyl‐cysteine PeptidesHelvetica Chimica Acta, 1980