Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients
- 1 August 2002
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 16 (12) , 1684-1686
- https://doi.org/10.1097/00002030-200208160-00016
Abstract
In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.Keywords
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