Somatostatin in the pancreas and hypothalamus of obese mice

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Abstract
The pancreatic content of somatostatin, insulin, and glucagon and the hypothalamic content of somatostatin were examined inob/ob mice at various ages and in goldthioglucose-obese mice. The total pancreatic content of somatostatin was increased inob/ob mice compared to controls: 92 ng vs 75 ng (a 22% increase) at 2 months of age; 208 ng vs 131 ng (a 60% increase) at 6 months of age; and 184 ng vs 118 ng (a 60% increase) at 8 months of age. The total pancreatic content of glucagon inob/ ob mice was already enhanced by 70% over controls at 2 months of age (301 ng vs 173 ng) and did not increase further at later stages, whereas that of insulin progressively rose with age. In goldthioglucoseobese mice the pancreatic content of insulin was also increased but to a lesser extent than inob/ob mice; the pancreatic levels of somatostatin and glucagon were unaltered. In bothob/ob mice (regardless of age) and goldthioglucose-obese mice, there was no significant change in the hypothalamic content of somatostatin compared with that of lean controls.