Somatostatin: Widespread Abnormality in Tissues of Spontaneously Diabetic Mice
- 2 December 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4320) , 930-931
- https://doi.org/10.1126/science.337488
Abstract
Diabetic mice of the C57BL/6J obob and C57BL/Ks dbdb strains show a reduction in pancreatic somatostatin concentration accompanied in the obob strain by a striking decrease in the number of somatostatin-containing cells in the islets. Somatostatin concentration is also decreased in the stomach but increased in the hypothalamus. These findings suggest different control mechanisms for somatostatin in the hypothalamus compared to the gut and pancreas and exclude a primary genetic abnormality of somatostatin cells in the mutants.This publication has 14 references indexed in Scilit:
- DECREASED PANCREATIC SOMATOSTATIN (SRIF) CONCENTRATION IN SPONTANEOUSLY DIABETIC MICEEndocrinology, 1976
- Reproductive Hormonal Function in the Genetically Obese (ob/ob) MouseEndocrinology, 1976
- Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.Proceedings of the National Academy of Sciences, 1976
- INCREASED SOMATOSTATIN CONTENT OF ISLETS FROM STREPTOZOTOCIN‐DIABETIC RATSClinical Endocrinology, 1976
- Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.Proceedings of the National Academy of Sciences, 1975
- Role of the thyroid in the development of the obese-hyperglycemic syndrome in mice (
ob ob )Metabolism, 1974 - The influence of genetic background on the expression of the obese (ob) gene in the mouseDiabetologia, 1973
- Effects of parabiosis of obese with diabetes and normal miceDiabetologia, 1973
- Kinetics of Immunoreactive Insulin Release in Obese Hyperglycemic Laboratory Rodents*Endocrinology, 1973
- Stereological Principles for Morphometry in Electron Microscopic CytologyPublished by Elsevier ,1969