Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Open Access
- 1 April 1990
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 10 (4) , 1492-1497
- https://doi.org/10.1128/mcb.10.4.1492
Abstract
The multifunctional actions of transforming growth factor beta 1 (TGF-beta 1) indicate that it has a pivotal control function in many physiological and pathological processes. An important property of TGF-beta 1 is its ability to activate its own mRNA expression and thereby increase its own secretion. Two distinct regions of the promoter of the TGF-beta 1 gene are responsive to autoregulation: one 59 to the upstream transcriptional start site and another located between the two major start sites. In both promoter regions, autoinduction is mediated by binding of the AP-1 (Jun-Fos) complex. An important contribution to this positive regulation is the autoactivation of c-jun transcription by AP-1. Cotransfection of antisense c-jun or antisense c-fos expression vectors prevents TGF-beta 1 autoinduction. These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction. Induction of jun expression by TGF-beta 1, as well as jun autoinduction, may amplify the action of TGF-beta 1 during normal development and oncogenesis. ImagesThis publication has 28 references indexed in Scilit:
- Prolonged activation of jun and collagenase genes by tumour necrosis factor-αNature, 1989
- The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1Published by Elsevier ,1988
- The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genesCell, 1988
- Transcriptional autoregulation of the proto-oncogene fosNature, 1988
- The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding SitesScience, 1988
- Possible positive autocrine feedback in the prereplicative phase of human fibroblastsNature, 1987
- Purified transcription factor AP-1 interacts with TPA-inducible enhancer elementsCell, 1987
- Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorCell, 1987
- Accurate transcription initiation on a purified mouse β-globin DNA fragment in a cell-free systemCell, 1980
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979