Complete occlusion of a renal artery branch on glomerular and tubular function

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Abstract
Experiments were made on anesthetized, laparotomized dogs to define alterations in glomerular and tubular function occurring when a branch of the left renal artery is occluded. Diuresis was induced by intravenous infusion of glucose, NaCl or urea solutions. Branch-artery occlusion on the left induced variable increases in filtration rate/tubule on the left only and increased fraction of filtered water excreted (V/Ccr) from both kidneys except when the left kidney was denervated during operative preparation. V/Ccr increased whether or not filtration/tubule increased. Branch-artery occlusion distorted the usual relationship between urine solute concentration and urine flow but not between urine solute concentration and V/Ccr, indicating that increased urine flow/tubule was osmotically induced and not a water diuresis. Thus, reduction of functional renal mass from branch-artery occlusion, frequently and inexplicably increased filtration/tubule in the ipsilateral kidney and independently initiated bilateral decrease in solute and water reabsorption that may have been mediated via the sympathetic nervous system.

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