Effects of acute administration of ethane hydroxydiphosphonate (EHDP) on skeletal scintigraphy with technetium-99m methylene diphosphonic acid (Tc-MDP) in the rat
- 1 July 1981
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 54 (643) , 592-596
- https://doi.org/10.1259/0007-1285-54-643-592
Abstract
A study has been performed in the rat to assess the effect of EHDP on the distribution of 99Tcm-labelled MDP used for skeletal imaging. Profound alterations in bone, kidney and blood levels were observed. These observations cast doubt on the value of bone scans for monitoring the therapeutic effect of diphosphonates.Keywords
This publication has 14 references indexed in Scilit:
- EFFECTS OF DISODIUM DICHLOROMETHYLENE DIPHOSPHONATE ON PAGET'S DISEASE OF BONEThe Lancet, 1979
- The uptake by the canine tibia of the bone-scanning agent 99mTc-MDP before and after an osteotomyThe Journal of Bone and Joint Surgery. British volume, 1978
- Intense Concentration of Technetium-99m Pyrophosphate in the Kidneys of Children Treated with Chemotherapeutic Drugs for Malignant DiseaseRadiology, 1978
- The use of adjunctive drugs to alter uptake of 99mTc-Sn-pyrophosphate by myocardial lesions and boneLife Sciences, 1978
- Fibrodysplasia (myositis) ossificans progressiva treated with disodium etidronateClinical Radiology, 1978
- The scintigraphic findings in Paget's disease of boneClinical Radiology, 1976
- TECHNETIUM 99M LABELED DIPHOSPHONATE BONE SCANNING IN PAGET’S DISEASEAmerican Journal of Roentgenology, 1974
- Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkeyToxicology and Applied Pharmacology, 1972
- The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphatesCalcified Tissue International, 1969
- Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivoScience, 1969