Effect of 2-Diethylaminoethyl 4-Methylpiperazine-1-Carboxylate on Influenza Viruses in Tissue Culture

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Abstract
Summary Graded concentrations of 2-diethylaminoethyl 4-methylpiperazine-1-carboxylate produced graded inhibition of influenza virus growth in Rhesus monkey kidney cultures as measured by hemagglutination and infectivity titration. The piperazinecarboxylate was effective against strains of influenza A, A1, A2, and the Great Lakes strain of influenza B, but it was not effective against the Lee strain in influenza B. The compound was most effective when added to the culture at the time of virus inoculum. When the multiplicity of infection was relatively low, the piperazinecarboxylate inhibited viral growth even when added after infection. The compound did not inactivate the virus on contact and it did not interfere with the adsorption of the virus to the cells. It appears to act by interfering with the penetration of the host cells by the virus. The compound has a mode of action and an antiviral spectrum similar to that reported for 1-adamantanamine.