Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats.

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Abstract
In order to elucidate the effect of ginsenoside-Rb2 on lipid metabolism, a time course experiment was carried out in rats. The first phenomenon observed was a stimulation of glucose-6-phosphate dehydrogenase activity beginning 4 h after the administration of ginsenoside-Rb2. At this time, a slight increase of acetyl-coenzyme A carboxylase activity was observed, and a significant increase was noted 16 h after the treatment. The maximum increase in malic enzyme activity was observed at 12 h. An increase in the lipolytic activity of lipoprotein lipase was observed 4 h after the i.p. administration of ginsenoside-Rb2, reaching a maximum (262%) 16 h after the treatment, while a repressive effect was observed on hormone-sensitive lipase activity throughout the experimental period. Administration of ginsenoside-Rb2 to rats also increased the triglyceride content in adipose tissue. Ginsenoside-Rb brings about the accumulation of triglyceride in adipose tissue as a result of its stimulating action on the lipogenic pathway.