Biosynthesis of Hyaluronic Acid in Tissue Cultures of Human Synovial Membrane.

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Abstract
The production of acid mucopolysaccharides in tissue cultures was studied by determining the increase of viscosity and the increase of mucopolysaccharide hexosamines. The results indicated that, hyaluronic acid was the chief mucopolysaccharide produced. An idea of the quality of the hyaluronic acid produced was attained by calculating the intrinsic viscosity. The values of this viscosity varied from one case to another, but kept rather constant from week to week.