CYTOPHOTOMETRIC AND CYTOGENETIC CHARACTERISTICS OF PRIMARY HEPATOMAS INDUCED IN WISTAR RATS BY AFLATOXIN-B1
- 1 January 1981
- journal article
- research article
- Vol. 28 (2) , 151-157
Abstract
Karyograms of the primary hepatomas induced in Wistar rats by aflatoxin B1 exhibited hypodiploid chromosome sets and destruction of the chromosomes. Cytophotometric investigations showed a decrease of DNA content in the neoplastic cells, even to .apprx. 40% of DNA content in the normal hepatocytes in rats. In the neoplastic destruction of the chromatin material in these hepatomas breaks and deletion of the chromatids predominate.This publication has 12 references indexed in Scilit:
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