DEVELOPMENT OF VIRILIZATION DURING PREGNANCY

Abstract
A patient who twice developed virilization during pregnancy was studied. She excreted excessive amounts of 17-ketosteroids (280 mg in a 24-hour urine-speci-men) ante partum which returned to normal levels during the post partum period. Urinary pregnanediol, estrogen and gonado-tropic substances were normal. At operation both ovaries were found to contain numerous nodules which consisted of hyperplas-tic lutein cells.
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