Thioctic Acid Content and Pyruvate Oxidation in Ethionine-Damaged Rat Livers.

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Abstract
Elevated blood pyruvate levels and diminished hepatic mitochondrial pyruvate oxidation were observed in ethionine-fed rats. The hepatic total and mitochondrial thioctic acid content were reduced. Failure of in vitro addition of thioctic acid to stimulate mitochondrial pyruvate oxidation, failure of thioctic acid injection to increase diminished mitochondrial thioctic acid content, normal renal thioctic acid content, and unimpaired urinary thioctic acid excretion suggest that total body thioctic acid synthesis is not reduced but that hepatic thioctic acid "binding" is impaired in rats fed a diet containing ethionine.