Effect of Cortisone upon Vascular Responsiveness of Potassium-Deficient and Normal Rats.

Publisher Website
Google Scholar
Abstract
Hypotension was induced in intact rats by dietary deprivation of K. Cortisone in such rats rapidly restored their blood pressures to normotensive levels. In these animals as well as in intact and uninephrectomized rats, with and without a ligature about the remaining kidney, and which were fed stock ration, cortisone did not appear to alter significantly their vascular responsiveness to pressor drugs. The data suggest that the restorative effect of cortisone upon blood pressure of K-depleted, hypotensive rats is not accounted for by augmentation of vascular responsiveness to pressor substances.