Vasoconstriction in the Cheek Pouch of the Hamster Following Treatment With Cortisone

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Abstract
Blood vessels in the everted, transilluminated cheek pouch of the hamster were observed microscopically following subcut. injns. of cortisone acetate. Either 12 daily repeated or single doses produced marked vasoconstriction, which began around 9 days after the 1st injn. and disappeared in from 3 to 7 wks. The time course of vasoconstriction and recovery was about the same for single or repeated doses. The threshold chronic dose of cortisone was about 0.3 mg. daily, and the threshold single dose was 5 mg. Controls were completed for the preserving and suspending agents. Blood pressures and blood vessels in the mesoappendix were normal during the vasoconstriction in the cheek pouch.