THE COAGULATION DEFECT IN HEMOPHILIA. THE EFFECT IN HEMOPHILIA OF INTRAMUSCULAR ADMINISTRATION. OF A GLOBULIN SUBSTANCE DERIVED FROM NORMAL HUMAN PLASMA 1

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Abstract
A globulin substance prepared from normal cellular-free plasma, by isoelectric precipitation, accelerates the coagulation of both hemophilic and normal blood in vitro in a quantitative manner. The material prepared from hemophilic plasma in an identical manner is deficient in clot-promoting property. Normal "globulin substance," administered either intraven. or intramuscularly, is effective in reducing the coagulation time of hemophilic blood. Following the initial injection of "globulin substance" into hemophilic subjects a temporary refractory phase is established. During this period the coagulation time is little affected by repeated injections although the concn. of "globulin substance" in the injected patient''s blood steadily increases.