HEMOPHILIA. II. SOME PROPERTIES OF A SUBSTANCE OBTAINED FROM NORMAL HUMAN PLASMA EFFECTIVE IN ACCELERATING THE COAGULATION OF HEMOPHILIC BLOOD

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Abstract
Upon dilution and acidification of filtered normal plasma there was formed a globulin precipitate, which, either fresh or dried in vacuo, contained a clot-promoting substance for hemophilic blood. This substance was effective both in vitro and in vivo. When the above procedure was applied to hemophilic plasma an approximately equivalent amt. of precipitate was formed, the saline suspension of which had very little ability to hasten the clotting of hemophilic blood. In respect to clotting activity, "globulin substance" so prepared from normal plasma is thermolabile, insoluble in water at pH 6.5, but soluble in isotonic saline. It was not ultrafilterable, but it did pass through a Berkefeld filter. Its range of optimal precipitation from plasma was between pH 5.9 and 6.4.

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