Hyperglycemia and Increased Liver Glycogen in Rats After X-Irradiation.

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Abstract
A quantitative study was made of the effect of whole-body X-irradiation on liver glycogen and blood sugar levels of the rat. Rats pre-fasted 24 hours, were exposed to 550, 750, 1200, 2500 or 5000 r and analyses made 24 and 48 hours later. As the dose of radiation increased, the percentage of liver glycogen at 24 hours after irradiation also increased. At all doses except 5000 r the percentage of liver glycogen was about the same at 24 hours and 48 hours after irradiation. In no case did the liver glycogen levels of the fasting, X-irradiated rat exceed that of the fed, normal animal. Blood sugar levels were elevated during the first 24 hours after the time of irradiation and continued to increase over the next 24 hours.

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