Zinc chloride induced stereoselection in syntheses of α-amino-β-hydroxy acid derivatives
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 682-683
- https://doi.org/10.1039/c39910000682
Abstract
Schiff bases formed from condensation of glycine esters with diphenylmethyleneamine have been silylated followed by condensation with aliphatic and aromatic aldehydes at room temperature in the presence of catalytic amounts of ZnCl2; the syn-condensation products are obtained in good yield and stereoselectivity, especially for aromatic aldehydes, and the sense of Stereoselection reverses in the presence of stoichiometric or excess of ZnCl2.Keywords
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