EFFECTS OF 17-BETA-ESTRADIOL ON THE ISOLATED RABBIT HEART

  • 1 May 1986
    • journal article
    • research article
    • Vol. 281  (1) , 57-65
Abstract
We have studied the effects of 17.beta.-estradiol on the left ventricular pressure and on the coronary perfusion pressure in isolated rabbit heart, in order to evaluate the action of this hormone on the myocardial contractility and on the coronary resistances. 17.beta.-Estradiol has induced a negative inotropic effect starting from a concentration of 10-6 M and a vasodilation starting from 10-7 M when administered on a vasopressin-induced coronary spasm. These effects are not related to sex or to .alpha.-, .beta.-adrenergic, histaminergic, anaesthetic-like mechanisms, but seem to interfere with calcium transport.