THE IN VITRO ACTIVITY OF MOXALACTAM AGAINST 430 CLINICAL, BACTERIAL ISOLATES

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Abstract
The in vitro activity of the novel .beta.-lactam antibiotic moxalactam against 430 bacterial isolates was determined by an agar dilution method. Moxalactam was highly active against Enterobacteriaceae including indole-positive Proteus and Providencia, all isolates being susceptible to 1.0 .mu./ml or less. The drug was somewhat less active against gram-positive cocci and Pseudomonas aeruginosa; enterococci were highly resistant. All Haemophilus influenzae isolates were inhibited by 0.06 .mu.g/ml or less. Activity against Bacteroides fragilis was good but wide variations of minimal inhibitory concentrations were noted. Moxalactam may become a useful alternative to the aminoglycosides in the treatment of serious infections (human) caused by gram-negative bacteria.

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