Metabolism of Volatile Anesthetics
- 1 May 1965
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 26 (3) , 348-357
- https://doi.org/10.1097/00000542-196505000-00013
Abstract
Evidence has accumulated to the effect that the volatile anesthetics are biodegradable. Direct evidence was shown for the most popular and potent anesthetics, diethyl ether, chloroform, halo-thane and methoxyflurane. Indirect evidence for the biotransformation of other less potent anesthetics can be shown. This information offers a fresh approach to certain questions concerning the action of anesthetics and the toxicity of the anesthetics. This will place the anesthetics in a position to be studied as chemical reactants rather than as physical inhibitors and offer a more positive approach to the study of their mechanism of action.Keywords
This publication has 15 references indexed in Scilit:
- Effects of Nitrous Oxide Inhalation on Hemopoiesis in RatsAnesthesiology, 1963
- Pharmacology and toxicology of trichloroethylene: A critical review of the world literatureClinical Pharmacology & Therapeutics, 1961
- A Molecular Theory of General AnesthesiaScience, 1961
- An enzyme from rat liver catalysing conjugations with glutathioneBiochemical Journal, 1961
- REDUCTION OF CARBON TETRACHLORIDE IN VIVO AND REDUCTION OF CARBON TETRACHLORIDE AND CHLOROFORM IN VITRO BY TISSUES AND TISSUE CONSTITUENTS1961
- Studies in detoxication. 79. The metabolism of cyclo[14C]hexane and its derivativesBiochemical Journal, 1959
- The enzymic cleavage of aromatic ethersBiochemical Journal, 1956
- Metabolism of ethers in the rabbit. 2. Nuclear-substituted anisolesBiochemical Journal, 1955
- The liberation of chloride ions from organic chloro compounds by tissue extractsBiochemical Journal, 1952
- ENZYMATIC DEHALOGENATION OF CERTAIN BROMINATED AND CHLORINATED COMPOUNDSJournal of Biological Chemistry, 1948