Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro
Open Access
- 1 February 1980
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 41 (2) , 277-284
- https://doi.org/10.1038/bjc.1980.40
Abstract
Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function of drug concentration. The data allow a mathematical description to be made of the interdependence of MTX concentration and drug exposure in relation to cell survival.Keywords
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