Sunscreens block the induction of epidermal ornithine decarboxylase by ultraviolet-B radiation: a new way of evaluating sunscreen efficacy in vivo

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Abstract
Two proprietery sunscreen preparations containing p-aminobenzoic acid [PABA] and sulisobenzone, respectively, were tested for their ability to block the induction of ornithine decarboxylase by UV-B in the epidermis of the hairless mouse. Both preparations were effective, the sunscreen treated animals requiring more radiation for ornithine decarboxylase induction. The UV dose-response gradients were reduced by a mean factor of 7.35 (sulisobenzone) and 15 (PABA). These figures correlate well with other in vivo sunscreen assays. This new method provides a simple and reproducible way of evaluating sunscreens in vivo.