Bradykinin and Anaphylactic Shock in Dogs, Guinea-Pigs and Rabbits

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Abstract
The changes of bradykininogen level in plasma during anaphylactic shock in dogs, guinea-pigs and rabbits have been studied. No detectable decrease of bradykininogen was found in six dogs following heavy (in two cases lethal) anaphylactic shock. In only two of seven guinea-pigs it was found a significant decrease of bradykininogen following protracted anaphylactic shock as induced by prior treatment with neo-antergan. A significant bradykininogen consumption was found in all the rabbits exhibiting a lethal anaphylaxis, in two of the six cases the decrease exceeding 50 % of the initial level. It is concluded that only in rabbits the amount of bradykininogen consumed during anaphylactic shock permits to ascribe to bradykinin a significant, although perhaps not essential, role in the pathogeny of this syndrom.

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