Uncoupling reagents and metabolism. 4. Effects of salicylate administration in the rat on the incorporation of 14C from labelled glucose and acetate into the soluble intermediates of isolated liver and brain

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Abstract
The effects of single and repeated injections of salicylate in the rat on the incorporation of C14 from labelled substrates into the soluble intermediates of isolated liver and brain preparations have been studied. The total incorporation of radioactivity from [Cl4]glucose or [2-Cl4]acetate in liver and brain was not altered by the injections. The distribution of C14 from [C14]-glucose in liver was affected by both single and repeated injections of salicylate. The main changes were a decreased incorporation of radiocarbon into alanine, sugar phosphates and nucleotides and an increased incorporation into glutamic acid and lactic acid. The accumulation of C14 into maltose was decreased by the single injections and increased by the repeated injections. Some implications of these results are discussed.