DIMINISHED ENDOGENOUS MORNING EOSINOPENIA IN BLIND SUBJECTS

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Abstract
The diurnal variations of the circulating eosinophils in man have been well established (Rud, 1947; Fisher & Fisher, 1951; Best & Samter, 1951; Halberg et al., 1951; Donato & Slrumia, 1952). The night levels of eosinophils are considerably higher than the day levels. The most characteristic phase of this variation is the morning drop of eosinophils and this phenomenon was termed »endogenous morning eosinopenia« (Halberg, Cohen & Flink, 1951). As in the case of any other biological change, it cannot be expected to occur in every single case, but it exists in normal people as a group phenomenon. These variations are related to adrenocortical activity, as increased excretion of 17-ketosteroids and of neutral reducing lipids after awakening have been reported (Pincus, Romanoff & Carlo, 1948). The endogenous eosinopenia, which was observed in man as well as in animals, was assumed to be related to the initiation of »daily activities« (Halberg