Cross-Resistance Patterns of Mutants Resistant to Streptomyces Phages

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Abstract
Strains of Streptomyces griseus, S. venezuelae, S. olivaceus and S. cyaneus, selected for resistance to one bacteriophage, frequently became resistant to other bacteriophages. Based on viral host range, the biological affinities of the organisms studied may be expressed as a continuous series: S. venezuelae strain S13[long dash]S. griseus strain S86[long dash]S. griseus strain S104[long dash]S. olivaceus strain S11[long dash]S. griseus strain S34[long dash]S. griseus strain S1945 [long dash]S. cyaneus strain S45. Twelve bacteriophages of different origin were arranged into allied groups on the basis of cross-resistance patterns. In one instance, resistance to one bacteriophage conferred immunity to all other phages tested. Conversely, selection for resistance to one bacteriophage rarely resulted in sensitivity to a 2d phage. Lysogenization was not responsible for the actinophage resistance.

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