Results of Long‐Term Carcinogenicity Bioassay on Vinyl Acetate Monomer in Sprague‐Dawley Rats
- 1 December 2002
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 982 (1) , 106-122
- https://doi.org/10.1111/j.1749-6632.2002.tb04927.x
Abstract
Vinyl acetate monomer (VAM) was administered in drinking water supplied ad libitum at doses of 5,000, 1,000, and 0 ppm (v/v) to 17‐week‐old Sprague‐Dawley rats (breeders) and to 12‐day embryos (offspring). Treatment lasted for 104 weeks; thereafter, animals were kept under control conditions until spontaneous death. VAM was found to cause an increase in total malignant tumors and in carcinomas and/or precursor lesions of the oral cavity, lips, tongue, esophagus, and forestomach. Based on these data, VAM must be considered a multipotent carcinogen.Keywords
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