Characterization of human haptoglobin cDNAs coding for α2FSβ and α1Sβ variants
- 12 March 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 168 (1) , 103-107
- https://doi.org/10.1016/0014-5793(84)80215-x
Abstract
A human liver library, derived from a heterozygous (Hp2‐1) donor, has been used to isolate cDNA clones coding for the haptoglobin (Hp) α1Sβ and α2FSβ variants. DNA sequencing has shown that the two variants are identical except for the αF duplicated segment in Hp α2FSβ. Four nucleotide changes have been found between the phenotypically different F and S regions of the Hp α2 gene, resulting in an Asp,Lys/Asn,Glu substitution.Keywords
This publication has 16 references indexed in Scilit:
- Identification and characterization of human haptoglobin cDNA.Proceedings of the National Academy of Sciences, 1983
- Biosynthesis, intracellular processing and secretion of haptoglobin in cultured rat hepatocytesBiochemical and Biophysical Research Communications, 1983
- Biosynthesis of rabbit haptoglobin: Chemical evidence for a single chain precursorFEBS Letters, 1983
- Sequence of human haptoglobin cDNA: evidence that the α and β subunits are coded by the same mRNANucleic Acids Research, 1983
- Covalent structure of human haptoglobin: a serine protease homolog.Proceedings of the National Academy of Sciences, 1980
- Intracellular protein topogenesisProceedings of the National Academy of Sciences, 1980
- [56] RNA polymerase nascent product analysisPublished by Elsevier ,1980
- A new method for sequencing DNA.Proceedings of the National Academy of Sciences, 1977
- Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.Proceedings of the National Academy of Sciences, 1975
- Perspectives — Past, Present, and FuturePublished by Elsevier ,1975