Physiological Aspects of Aging. I. Efficiency of Absorption and Phosphorylation of Radiothiamine.

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Abstract
Absorption of an oral dose of 120 [mu]g of C14-labeled thiamine by the rat was studied as a function of age and the state of thiamine nutrition. Approximately 95% was absorbed up to an age of 19-20 months, when the efficiency declined to about 75% at 22-24 months. Absorption by thiamine-deficient animals was not different from that of rats receiving normal or excess quantities of thiamine in the diet. The proportion of absorbed radiothiamine in esterified and unesterified forms in the livers of rats 22-24 months old was less than that in rats 5-8 months old.