The influence of hydrolysates of hyaluronate upon hyaluronidase production by micro-organisms

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Abstract
Potassium hyaluronate, hydrolyzed by testicular hyaluronidase, stimulates hyaluronidase production by streptococcus C7 or Clostridium welchii A118d, as well as the unhydrolyzed polysaccharide. When hydrolyzed by streptococcal or C. welchii enzymes, it does not stimulate enzyme production by strep. C7. The streptococcal hydrolysate stimulates enzyme production by C. welchii A118d; the C. welchii hydrolysates have only a small influence on this organism. Hydrolysis of hyaluronate by mild treatment with acid destroys the ability of the polysaccharide to enhance hyaluronidase production by strep. C7.

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