BIO ASSAY OF MINERALOCORTICOIDS: RELATIONSHIP OF STRUCTURE TO PHYSIOLOGICAL ACTIVITY

Publisher Website
Google Scholar
Abstract
A series of 32 compounds, related in structure to the adreno-cortical hormones, have been tested for effect on excretion of Na and K in adrenalectomized rats. Most modifications of the structure of 11-desoxycorticosterone result in reduced Na-retaining activity. Four synthetic compounds of high activity have in common the basic structure of 11-desoxycorticosterone with modifications about carbons 9 or 10. The most potent artificial compounds studied are the 9 alpha-chloro derivatives of cortisone and hydrocortisone. Aldosterone, isolated from adrenal cortical extract, and a corticosteroid presumed to be aldosterone, extracted from human urine, are considerably more potent than any of the other compounds studied.