Biological Studies of Lipophilic Mdp-Derivatives Incorporated in Liposomes
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 10 (6) , 511-522
- https://doi.org/10.3109/08820138109055701
Abstract
Adjuvant activities of fatty acid derivatives of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) in saline, emulsified in Incomplete Freund Adjuvant (IFA) or incorporated in liposomes were compared. All derivatives were active when given in saline. The potency of MDP-L-Ala-glycerol mycolate was highly enhanced by administration in IFA or after incorporation in liposomes. These procedures had no effect on the activity of MDP-α-methyl-α-n-butyl ester and MDP-α-methyl-α-n-decyl ester although the presence of MDP could be demonstrated at the surface of the liposomes by anti-MDP antibodies.This publication has 16 references indexed in Scilit:
- SYNTHESIS OF N-ACETYL-MURAMYL-l-ALANYL-d-GLUTAMIC-α-AMIDE(MDP) OR -α-METHYL ESTER DERIVATIVES, BEARING A LIPOPHILIC GROUP AT THE C-TERMINAL PEPTIDE ENDInternational Journal of Peptide and Protein Research, 2009
- Synthesis of conjugates containing
acetylmuramyl- (MDP). Their use as hapten-carrier systemsl -alanyl-d -isoglutaminylMolecular Immunology, 1980 - Cord factor and related synthetic trehalose diestersSpringer Seminars in Immunopathology, 1979
- Vaccination of Experimental Monkeys Against Plasmodium falciparum : A Possible Safe AdjuvantScience, 1978
- In Vivo and in Vitro Stimulation of Nonspecific Immunity by the -D-p-Aminophenyl Glycoside of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine and an Oligomer Prepared by Cross-Linking with GlutaraldehydeThe Journal of Infectious Diseases, 1978
- Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.Proceedings of the National Academy of Sciences, 1977
- Modulation of the immune response by a synthetic adjuvant and analogs.Proceedings of the National Academy of Sciences, 1976
- Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble componentsCellular Immunology, 1976
- Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivativesBiochemical and Biophysical Research Communications, 1974
- Permeability properties of liposomes prepared from dipalmitoyllecithin, dimyristoyllecithin, egg lecithin, rat liver lecithin and beef brain sphingomyelinBiochimica et Biophysica Acta (BBA) - Biomembranes, 1974