Genetic Influence of the Rs Locus on Susceptibility to Avian Tumor Viruses. I. Neoplasms Induced by RPL12 and Three Strains of Rous Sarcoma Virus

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Abstract
Matings producing progeny of known genotype at the Rs locus were assembled. The influence of this locus, which has a profound effect on susceptibility to the Bryan standard strain of Rous sarcoma virus (BS-RSV), on susceptibility to four other strains of avian tumor viruses was investigated. It was found that the homozygous-resistant chickens (rs rs) were also comparatively resistant to neoplasms induced by the RPL12 erythroblastosis-lymphomatosis virus inoculated intravenously into embryos. However, this locus had no detectable influence on the number of pocks or the proportion of chorioallantoic membranes showing no pocks after inoculation with the Harris, Schmidt-Ruppin, and RSV2 strains of Rous sarcoma virus. The possible relationship of antigenic makeup and genetic specificity is discussed.