The Renal Changes in NZB/B1 and NZB-NZW F1 Hybrid Mice. Light and Electron Microscopic Studies

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Abstract
Striking renal involvement occurs in NZB and particularly in NZB-NZW F1 hybrid mice. In this paper we describe the morphologic changes observed by light and electron microscopy in the kidneys of both strains during a study of the natural history of the disease. A semiquantitative analysis of the histologic findings was made and was compared with previously published observations in human systemic lupus erythematosus. In the NZB strain, normal kidneys were found in 30 mice of all ages up to 96 weeks; glomerulitis, in which intraglomerular thrombi were often observed, in 19; and glomerulonephritis in four. In the NZB-NZW F1 hybrid, nine kidneys were considered normal (10–28 weeks of age); five had glomerulitis (32–42 weeks); and 17 had glomerulonephritis (34–84 weeks). Morphologically, there are definite similarities between human lupus glomerulitis and the disease seen in the NZB mouse; and, between human lupus glomerulonephritis and that seen in the NZB-NZW F1 hybrid.

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